1997;12:22716. Article Research from 2017 found that there was not enough evidence to support using acupuncture to treat infertility in women with polycystic ovary syndrome. Allocation will be concealed in sequentially numbered, opaque, and sealed envelopes containing the randomization assignments. This could have affected the results of their studies. Patients who conform to the following criteria will be included: Meets the diagnosis of infertility and is trying to conceive; Willing to participate in this study and sign an informed consent form. And you may even turn to complementary methods likeacupuncture, a natural practice thats thousands of years old. Almost all of the studies were designed in detail with the exception of two conference papers [46, 47]; therefore, we extracted more relevant observation indicators. The secondary outcomes include endometrial pattern, resistance index (RI) and pulsatility index (PI) of bilateral uterine artery and endometrium blood flow, serum estradiol (E2) and progesterone (P), and pregnancy rate. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Yuan X, Saravelos SH, Wang Q, Xu Y, Li TC, Zhou C. Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF-ICSI cycles. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Study results will be presented at national and international scientific meetings and be published in peer-reviewed and clinical journals. When the needle was pushed forward against the skin, it slid into the handle, and the entire needle appeared shortened. This study will use four levels of data monitoring to improve quality control. Accessibility We randomized 84 women with PCOS, aged 18-37 yr, to 16 wk of low-frequency EA, physical exercise, or no intervention. However, larger studies are needed to confirm that using a frequency of 2/100Hz electroacupuncture may improve IVF outcomes. Some people may use ear seeds to relieve symptoms of conditions such as chronic pain. Studies were categorized according to the type of control group: acupuncture vs. sham acupuncture and acupuncture vs. no intervention; other trials were excluded, such as acupuncture vs. some medication, real acupuncture with Chinese herbology vs. sham, acupuncture with Chinese herb, and acupuncture with medication vs. medication alone. Google Scholar. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Xia L, Meng Q, Xi J, Han Q, Cheng J, Shen J, et al. The trial will be conducted in the Department of gynecology, Chengdu University of Traditional Chinese Medicine Affiliated Hospital. Jo J., Lee Y. J., Lee H. Acupuncture for polycystic ovarian syndrome: a systematic review and meta-analysis. National Library of Medicine Acupuncture improves blood flow to the uterus. Fifteen studies [26, 2831, 33, 3743, 45, 47] examined live birth rate (LBR) in patients (n=5710) assigned true acupuncture or sham acupuncture; the LBR in the acupuncture group was higher than that in the control group (32.1% and 27.9%; OR: 1.34; 95% CI: 1.071.67; P=0.01) (Figure 3). Ethical approval has been obtained from the Sichuan Regional Ethics Review Committee on Traditional Chinese Medicine with an ethics approval number of 2019KL-072. Does acupuncture work to increase fertility? Gerhard I., Postneek F. Possibilities of therapy by ear acupuncture in female sterility. So E. W. S., Ng E. H. Y., Wong Y. Y., Lau E. Y. L., Yeung W. S. B., Ho P. C. A randomized double blind comparison of real and placebo acupuncture in IVF treatment. Fertil Steril. Remoh J, Ardiles G, Garca-Velasco JA, Gaitn P, Simn C, Pellicer A. Endometrial thickness and serum oestradiol concentrations as predictors of outcome in oocyte donation. Madaschi C., Braga D. P. A. F., Figueira R. d. C. S., Iaconelli A., Borges E. Effect of acupuncture on assisted reproduction treatment outcomes. First was the method used by Wu et al., which involved a superficial insertion in the shoulder and upper arm without manual or electrical stimulation [39]. An acupuncturist inserts very small, thin needles into specific points of a body to stimulate blood flow to that area. Endometrial thickness: a predictor of implantation in ovum recipients? However, the blunt needle use may be superior to true acupuncture at improving live birth rates. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Zhao J, Zhang Q, Wang Y, Li Y. Endometrial pattern, thickness and growth in predicting pregnancy outcome following 3319 IVF cycle. Fast Facts About Acupuncture for Fertility; How Does Acupuncture Help . Cleveland Clinic 1995-2023. Evidence for the use of blunt acupuncture to treat infertility is insufficient. MacPherson H, Altman DG, Hammerschlag R, Youping L, Taixiang W, White A, et al. Use of electroacupuncture and transcutaneous electrical - PubMed Complementary therapies are widely used by patients with infertility. A. Chinese Clinical Trials Registry ChiCTR2000029983. Patients who quit the study voluntarily or have poor clinical compliance during observation period or found to not conform to the inclusion criteria after enrolment will be considered as having dropped out. We avoid using tertiary references. Participants in the SEA group may get 36 sessions of electroacupuncture free of charge after the trial. Endometrial thickness affects the outcome of in vitro fertilization and embryo transfer in normal responders after GnRH antagonist administration. However, acupuncture did not show beneficial outcomes in other pregnancy-related factors such as ongoing pregnancy rate, oocytes retrieved, good-quality embryo rate, miscarriages, and ectopic pregnancy rate. Hum Reprod. To improve endometrial receptivity in infertile patients with thin endometrium, electroacupuncture prescription will be developed based on clinical practice and literature review. PLoS Med. government site. The endometrium undergoes complex changes in the circulation of estrogen and progesterone (P), which culminate at the mid-luteal phase of the menstrual cycle when it becomes receptive [2, 62, 63]. J Assist Reprod Genet. Ma S, Li D, Feng Y, Jiang J, Shen B. For many women who are trying to conceive, one of the most frustrating parts of the fertility process can be not responding well enough to the medications that the treatment can move forward. Strowitzki T, Germeyer A, Popovici R, von Wolff M. The human endometrium as a fertility-determining factor. We found clear advantages of acupuncture over blank control conditions in terms of the live birth rate, biochemical pregnancy rate, ongoing pregnancy rate, and clinical pregnancy rate. A recent study in the Journal of the American Medical Association (JAMA) found that acupuncture only caused a negligible (around 1 percent) increase in pregnancy outcomes, but other research has shown that acupuncture in conjunction with other fertility treatments increases success rates by 50 percent. Pulsatility index (PI) in the uterine arteries is considered valuable in assessing endometrial receptivity, and it was found to have decreased after EA treatment [24]. In the case of acupuncture for fertility, these acupoints are often in your abdomen, targeting your reproductive organs. The characteristics of the included studies are summarized in Table 1. Hum Reprod Update. Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, et al. He Y. Acupuncture treatment of male infertility: a systematic review. In summary, this review provides moderate evidence of the benefits of acupuncture for infertile women; this will enable medical researchers to consider using acupuncture to help infertile women conceive in future clinical practice. Can a Fertility Massage Really Help You Get Pregnant? Google Scholar. Hum Reprod. Paulson RJ. According to TCM theory, thin endometrium in infertile women combines with the deficiency of kidney essence, poor circulation of Qi and blood, and disharmony of thoroughfare and conception vessels. Role of acupuncture in the treatment of female infertility. HHS Vulnerability Disclosure, Help Could eating more nuts help boost memory later in life? Careers, Unable to load your collection due to an error. Acupuncture has been used to treat infertility extensively, including ovulatory dysfunction, in vitro fertilization and embryo transfer (IVF-ET), and male infertility. PubMed Trials 22, 73 (2021). The synergistic effect of electroacupuncture and bone mesenchymal stem cell transplantation on repairing thin endometrial injury in rats. Kasius A, Smit JG, Torrance HL, Eijkemans MJ, Mol BW, Opmeer BC, et al. What to know about cervical mucus and fertile discharge. All other outcomes will be evaluated before treatment, during the treatment of 1st, 2nd, and 3rd menstrual cycle, and 6months after treatment. Acupuncture may alleviate some of the undesirable symptoms of pregnancy like morning sickness, fatigue and depression. The study authors were contacted for clarifications, as needed. ST36, SP6, SP10, LI 4, and DU20, Ren 3, ST29, SP10, SP6, ST36, and LI 4. Two authors (Kewei Quan and Chuyi Yu) independently selected and reviewed all studies; any disagreements were resolved by discussion. 1994;9:3635. Ranisavljevic N, Raad J, Anahory T, Grynberg M, Sonigo C. Embryo transfer strategy and therapeutic options in infertile patients with thin endometrium: a systematic review. 2017;21:546. Hum Reprod Update. In TCM, the selection of acupoints should be individualized based on the presentation of the disease condition. Last medically reviewed on November 5, 2018, Sperm count is a key factor in fertility. After full-text screening, an additional 41 studies were removed. Google Scholar. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. MNT is the registered trade mark of Healthline Media. H7, LI4, GV20, ear AA55, CV3, CV4, CV6, LIV3, ST30, and SP8, bilateral LI4, SP6, SP9, ST36, ACU2: acupuncture 25min before and after ET, Before: PC6, SP8, LR3, GV20, ST29. By using this website, you agree to our Manheimer E., Zhang G., Udoff L., et al. Electro-acupuncture treatments were performed at 6h and 24h at BL-23 to BL-36 on both sides. EA at LR3, SP6, ST28, EX-CA1, RN6, and RN4 was able to reduce uterine artery blood flow impedance in patients undergoing in vitro fertilization [68]. Andersen D., Lssl K., Nyboe Andersen A., et al. If youre trying to get pregnant, you may be doing everything in your power to make it happen: Youve stopped your birth control, yourepreparing your bodyand youve begun tracking your menstrual cycles. The authors declare that they have no competing interests. Currently known, acupuncture mainly improves the endometrial receptivity by increasing endometrial blood perfusion or regulating hormone receptors [27, 32, 67]. Silva MR, Helio OA, Vaz OD, Martinez de Oliveira J. Subendometrial resistence and pulsatility index assessment of endometrial receptivity in assisted reproductive technology cycles. Risks associated with this study are minimal. It has been shown that thin endometrium leads to infertility [3]. Cancer Epidemiol Biomark Prev. 2010;7(6):3546. Smith C. A., de Lacey S., Chapman M., et al. The obligatory acupoints will include bilateral Tianshu (ST25), Zigong (EX-CA1), Sanyinjiao (SP6), Guilai (ST29), individual Zhongji (RN3), and Guanyuan (RN4). Consolidated Standards of Reporting Trials, Standardized Protocol Items: Recommendations for Interventional Trials, Standards for Reporting Interventions in Clinical Trials of Acupuncture, Transcutaneous electrical acupuncture point stimulation. However, there was no positive control group included in this study. Estradiol stimulates both increases in the size and number of myometrial and endometrial cells as well as changes in endometrial thickness [64]. Alieva E. A., Fanchenko N. D., Pshenichnikova T., Parshutin N. P., Gasparov A. S., Vetr M. The polycystic ovary syndrome and increased body mass. The control groups consisted of no, sham, and placebo acupuncture. Other treatments, such as vitamin E and l-arginine, were all base on small sample size, thus lack sufficient evidence of efficacy [51]. Shuai Z., Lian F., Li P., Yang W. Effect of transcutaneous electrical acupuncture point stimulation on endometrial receptivity in women undergoing frozen-thawed embryo transfer: a single-blind prospective randomised controlled trial. Thin endometrium negatively impacts the reproductive function. However, the true acupuncture group had a higher rate of clinical pregnancy than did the blank group [9, 10, 30, 3338, 40, 41, 4446] (n=2872) (43.5% vs. 34.4%; OR: 1.54; 95% CI; 1.281.85; P < 0.00001). Ho M, Huang LC, Chang YY, Chen HY, Chang WC, Yang TC, et al. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis. Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): extending the CONSORT statement. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. The PubMed, Embase . Smith, C. A., de Lacey, S., Chapman, M., Ratcliffe, J., Norman, R. J., Johnson, N. P., Fahey, P. (2018, May 15). 2011;96(3):5305. Grnbaum A. Scott says the benefits of acupuncture for fertility may include: If youre interested in acupuncture, check with your primary care physician, Ob/Gyn or reproductive endocrinologist/fertility specialist to be sure its OK for you to try. This analysis revealed that acupuncture does not affect fertility outcomes. Participants will receive 36 sessions over three menstrual cycles (12weeks in total), with the same acupoint prescription. Evid Based Complement Alternat Med. Evidence-Based Application of Acupuncture in Theriogenology - MDPI Teh WT, McBain J, Rogers P. What is the contribution of embryo-endometrial asynchrony to implantation failure? 1. When used as a treatment for infertility, proponents of acupuncture say it can help by: In this article, learn about why some people use acupuncture for fertility, as well as what the research says about its effectiveness. Acupuncture has been used to treat infertility extensively, including ovulatory dysfunction, in vitro fertilization and embryo transfer (IVF-ET), and male infertility. You can learn more about how we ensure our content is accurate and current by reading our. Acupuncture is the insertion of ultra-thin, sterile needles into specific acupuncture points on the body which reside on channels or meridians; these are pathways in both the exterior and . That being said, acupuncture is generally safe and has few risks. The included studies scored 7 points (Figure 2). In the study, endometrial blood perfusion will be assessed using the PI and RI of bilateral uterine artery as well as endometrium blood flow. Kewei Quan and Chuyi Yu contributed equally to this work and both acted as first authors. They will be trained and assessed before the trial. Its also been shown to help women who are already undergoing IVF have better outcomes. Some studies had control groups that received pharmaceutical or herbal medicine or oral contraceptives, which may interfere with the effects of acupuncture, so we excluded these studies. After: ST36, SP6, SP10, LI4, Before ET PC6, SP8, LR3 GV20, ST29. The first three of the secondary outcomes will be evaluated in the mid-luteal phase of 3rd menstrual cycle (the primary time frame) and the 1st menstrual cycle and 2nd menstrual cycle, as well as 6months after treatment (the secondary time frame) in comparison with the baseline (in the 1st menstrual cycle). 2001;79(4):279. Smith C. A., Ussher J. M., Perz J., Carmady B., de Lacey S. The effect of acupuncture on psychosocial outcomes for women experiencing infertility: a pilot randomized controlled trial. The practice is usually safe, but it's important to seek out a certified and licensed professional who's familiar with infertility care. The recruitment of patients will start on March 1, 2020, and it is expected that by December 31, 2020, the required sample size will be reached. Frontiers | An Overview of Systematic Reviews of Acupuncture for Acupuncture can also help prevent miscarriage in pregnant women. There is currently no conclusive evidence to suggest that acupuncture does or does not improve fertility. An Overview of Systematic Reviews of Acupuncture for Infertile Women All included studies [6, 7, 9, 10, 2547] examined clinical pregnancy rates; however, two studies [27, 47] failed to report them.
Wise Popcorn Snack Bags, 1 Gallon Bottle Pump Dispenser, Child Focused Business Ideas, Mishimoto Catless Downpipe Mustang Ecoboost, Acs Composite Military Discount, Fairline Squadron 42 For Sale, Mackie Dl32r 32-channel Digital Multitrack Usb Mixer, Side View Well Camera, 2002 F450 Dump Truck For Sale, Whatsapp Bulk Message Sender Codecanyon,
Wise Popcorn Snack Bags, 1 Gallon Bottle Pump Dispenser, Child Focused Business Ideas, Mishimoto Catless Downpipe Mustang Ecoboost, Acs Composite Military Discount, Fairline Squadron 42 For Sale, Mackie Dl32r 32-channel Digital Multitrack Usb Mixer, Side View Well Camera, 2002 F450 Dump Truck For Sale, Whatsapp Bulk Message Sender Codecanyon,