No adverse effects were reported from the human study. BMC Complement Altern Med. View abstract. A recent animal study examined a supplement combining royal jelly with other bee-derived substances and found a significant reduction in blood pressure. One small six-month human study demonstrated a 20% reduction in fasting blood sugar in healthy people who supplemented daily with royal jelly (10). The evidence that is available is from animal models. Healthline Media does not provide medical advice, diagnosis, or treatment. WebResearch has found a number of potential health benefits to royal jelly: Antibacterial Properties Royal jelly has demonstrated antibacterial properties against a range of bacteria. 1965;10:83-125. View abstract. Siavash M, Shokri S, Haghighi S, Shahtalebi MA, Farajzadehgan Z. Medicina (Kaunas). 2018;6(1):2. doi:10.3390/medicines6010002, Khoshpey B, Djazayeri S, Amiri F, et al. Allergic reactions to honey and royal jelly and their relationship with sensitization to compositae. 2008;35(4):222-224. Int Wound J. Taking royal jelly along with medications that lower blood pressure might cause blood pressure to go too low. 2017 Jan 6;12(1):e0169069. J Allergy Clin Immunol 1995;96:1004-7. View abstract. Improves mental health Stimulates physical functions for the elderly Helps to soothe the premenstrual syndrome Supports postmenopausal treatment of urinary and other issues However, most of the studies of royal jelly have been done on animals. Some studies suggest that royal jelly, taken alone or in combination with other herbal supplements, may improve function and limit additional damage in people living with chronic kidney disease. Though this data is encouraging, human research is needed. These can generally be stored for up to six months in the refrigerator or up to three years in the freezer. [Two cases of royal jelly allergy provoked the symptoms at the time of their first intake]. Nucl.Med.Biol. 1. Holist Nurs Pract. According to the research, 50 people with type 2 diabetes were given either a placebo or 1,000 milligrams (mg) of royal jelly three times daily. View abstract. Royal Jelly: Is It Good For But is it worth the expense? A., van Eck-Smit, B. L., and Booij, J. Synthesis and evaluation of iodinated TZTP-derivatives as potential radioligands for imaging of muscarinic M2 receptors with SPET. Royal jelly may slow blood clotting and intensify the effects of blood thinners like warfarin, leading to easy bruising and bleeding. Araki K, Miyata Y, Ohba K, et al. Potential Health Benefits of Royal Jelly Takahama, H. and Shimazu, T. Food-induced anaphylaxis caused by ingestion of royal jelly. With that said, royal jelly has been known to cause allergic reactions in some people, ranging from mild nasal symptoms to life-threatening anaphylaxis. Curr Ther Res Clin Exp 2002;63:344-53.. Yakoot M, Abdelatif M, Helmy S. Efficacy of a new local limb salvage treatment for limb-threatening diabetic foot wounds - a randomized controlled study. Prevention and treatment of chemotherapy and radiotherapy induced oral mucositis. View abstract. A good source of antioxidants Raw honey contains an array of plant chemicals that act as antioxidants. While these results are promising, human studies are lacking. 7 Natural Retinol Alternatives That Deserve a Spot on Your Shelf, Petroleum Jelly Is a Dry Skin StapleBut Is It Safe? Leung R, Thien FC, Baldo B, et al. Consider the following before using royal jelly: Royal jelly can cause a range of allergic reactions, from contact dermatitis to anaphylaxis. Allergol Immunopathol (Madr) 1998;26:288-90. Royal Jelly While honey is known for treating wounds, studies suggest royal jelly can also aid in wound healing, Axe says. 2022;14(19):4166. doi:10.3390/nu14194166, Dauglait G, Ukuraityt K, Jagelaviien E, Filipauskas A. Li JD, Cui L, Xu YY, Guan K. A case of anaphylaxis caused by major royal jelly protein 3 of royal jelly and its cross-reactivity with honeycomb. 2006;4(82). Royal Jelly View abstract. J.Nutr.Sci.Vitaminol. Conversely, a more recent human study did not notice any difference in wound healing between a control group and participants treating diabetic foot ulcers topically with royal jelly (14). Apitherapy uses honey and other products to help treat conditions like arthritis. View abstract. J.Pharm.Pharmacol. Kamakura, M., Moriyama, T., and Sakaki, T. Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly. The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor. 1978;98:139-145. Araki K, Miyata Y, Ohba K, et al. J.Altern.Complement Med. View abstract. It's rich in carbs, protein, amino acids, fatty acids, vitamins, and minerals. Nakaya, M., Onda, H., Sasaki, K., Yukiyoshi, A., Tachibana, H., and Yamada, K. Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. J.Dermatol. A. Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility. 2017;2017:1259510. doi:10.1155/2017/1259510, Peng CC, Sun HT, Lin IP, Kuo PC, Li JC. Multiple animal studies showed increased insulin sensitivity and an apparent protective effect on pancreatic, liver and reproductive tissue in obese, diabetic rats treated with royal jelly (17, 18, 19). Katayama, M., Aoki, M., and Kawana, S. Case of anaphylaxis caused by ingestion of royal jelly. Biosci.Biotechnol.Biochem. WebOverview Royal jelly is a milky secretion made by worker honeybees (Apis mellifera). Drug Saf 1997;17:342-56. View abstract. Here are the top 11 health. All rights reserved. Honey View abstract. 2006;30(2):175-183. This information may not fit your specific health circumstances. Mishima, S., Suzuki, K. M., Isohama, Y., Kuratsu, N., Araki, Y., Inoue, M., and Miyata, T. Royal jelly has estrogenic effects in vitro and in vivo. They don't call 'em busy for nothing. Leung, R., Thien, F. C., Baldo, B., and Czarny, D. Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations. View abstract. Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. J.Nutr.Sci.Vitaminol. (Tokyo) 2007;53(4):345-348. 2017;55(1):497-502. doi:10.1080/13880209.2016.1253110, Taavoni S, Barkhordari F, Goushegir A, Haghani H. Effect of royal jelly on premenstrual syndrome among Iranian medical sciences students: a randomized, triple-blind, placebo-controlled study. A separate study resulted in improved memory and reduced symptoms of depression in postmenopausal rats given royal jelly (21). Royal jelly contains bee-derived proteins, along with several antioxidants and antibacterial compounds, that are believed to afford health benefits to humans. If you are vegan or vegetarian, be sure that the gelcaps you choose do not contain animal-based gelatins. The benefits of raw honey including healing, skin care, and more. Pharm Biol. J.Wound.Care 2008;17(3):108-110. Well explain its benefits and side effects to watch for. Here are 12 potential benefits of royal jelly. Potential Health Benefits of Royal Jelly Mannoor MK, Shimabukuro I Tsukamotoa M Watanabe H Yamaguchi K Sato Y. Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB NZW F1 mice. Taking royal jelly by, Diabetes. Madar, J., Maly, E., Neubauer, E., and Moscovic, F. [Effect of bee royal jelly (gelee royale) on the cholesterol level, total lipids in the serum and on the fibrinolytic activity of plasma of elderly arteriosclerotic patients]. View abstract. Erem, C., Deger, O., Ovali, E., and Barlak, Y. Thank you, {{form.email}}, for signing up. WebMD does not provide medical advice, diagnosis or treatment. Always read the product label to see what other ingredients are included. Akush.Ginekol. To avoid interactions, advise your healthcare provider if you are planning to use royal jelly and include a list of all of the other drugs you are taking, whether they are prescription or over-the-counter. 2003;3(9):1313-1324. Folia Med.(Plovdiv.) Biosci.Biotechnol.Biochem. Relieves the symptoms of menopause A major study in 2011 found that four natural ingredients including royal jelly could diminish the symptoms of menopause and make the more manageable. Kanbur, M., Eraslan, G., Beyaz, L., Silici, S., Liman, B. C., Altinordulu, S., and Atasever, A. 2012 Dec 28;2(2):231-5. Royal jelly is not the same as honey, but its edible and generally thought safe to consume in a variety of forms, including royal jelly capsules and liquids. View abstract. The effects of royal jelly on liver damage induced by paracetamol in mice. 1. Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Honey Its also called honey bee milk, bee spit, and bee saliva. Royal Jelly Studies have shown that royal jelly may be taken in daily doses of up to 1,000 mg for three months with no notable side effects. View abstract. What is royal jelly? [Treatment of stenocardia with Vita-Apinol SPOFA. What You Should Know, Why You Should Care That All the Honeybees Are Dying, The 15 Best Fish Oil Supplements of 2023, According to Dietitians. Royal jelly View abstract. Like honey, royal jelly also comes from beehives. Andersen, A. H., Mortensen, S., Agertoft, L., and Pedersen, S. [Double-blind randomized trial of the effect of Bidro on hay fever in children]. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Royal jelly advocates claim it offers anti-aging benefits and boosts the immune system. Claims that eating royal jelly can help improve fertility stem from this fact. If you use royal jelly on an ongoing basis, be sure to stop treatment two weeks before a scheduled surgery to prevent excessive bleeding. Oral intake of royal jelly has protective effects against tyrosine kinase inhibitor-induced toxicity in patients with renal cell carcinoma: a randomized, double-blinded, placebo-controlled trial. 1988;1(1):13-15. Royal Jelly: Is It Good For However, nutrient composition varies considerably between sources of royal jelly (1). Royal Jelly Roselschozizdat Moskva 1964;1. Allergies to wheat, yeast and royal jelly: a connection between ingestion and inhalation? Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Since human research on the anti-aging benefits of oral or topical royal jelly use is insufficient, more studies are needed. When exposed to air, royal jelly can turn from a creamy yellow to a darker brown. View abstract. On some metabolic effects of the drug]. Climacteric 2021;24(2):164-70. 2023 Healthline Media LLC. View abstract. Nutrients. WebProteins Major royal jelly proteins (MRJPs) are a family of proteins secreted by honey bees. Immunopharmacology & Immunotoxicology. 2006;33(6):424-426. But the benefits of royal jelly in humans are also getting popular lately. What is Royal Jelly? Effects of royal jelly on bone metabolism in postmenopausal women: a randomized, controlled study. Royal jelly is a milky secretion produced by worker honey bees. 1995;96(6 Pt 1):1004-1007. View abstract. Exp.Gerontol. However, most applicable data is limited to animal and test-tube research. 2012;11:77. View abstract. Ingesting royal jelly is not 100% risk-free. Peptides 2004;25(6):919-928. The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial. 2017;17(1):392. doi:10.1186/s12906-017-1888-8, Kurek-Grecka A, Grecki M, Rzepecka-Stojko A, Balwierz R, Stojko J. Bee products in dermatology and skin care. Benefits N Z Med J 1996;109:325. One study revealed a significant reduction in chemotherapy-induced heart damage in rats supplemented with royal jelly (27). J.Ethnopharmacol. Royal jelly both used orally and topically may support wound healing and other inflammatory skin conditions. Hypercholesterolemia (high cholesterol) is a concerning disorder linked to atherosclerosis (hardening of the arteries), heart attack, and stroke. Conversely, another small human study determined no significant differences in cholesterol levels between participants treated with royal jelly and those on a placebo (10). 1960;45:2015-2021. "The exact mechanism through which royal jelly may extend lifespan is not well-understood, and human data is limited to cells in vitro," she explains. View abstract. Royal jelly may slow the aging process in several ways. Int.J.Mol.Med. Ugeskr.Laeger 1-13-1997;159(3):294-296. Mahboobi S, Jafarnejad S, Eftekhari MH. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. MedGenMed 2004;6:46. Contact Dermatitis 1983;9:452-5. Royal Jelly The family consists of nine proteins, of which MRJP1 (also called royalactin), MRJP2, MRJP3, MRJP4, and MRJP5 are present in the royal jelly secreted by worker bees. Yakoot M, Salem A, and Omar AM. 1968;14(8):798-805. Roger A, Rubira N, Nogueiras C, et al. It's also possible the benefits of royal jelly supplements extend way beyond firming and smoothing skin, Koestline says. Life Sci. Peacock S. Respiratory distress and royal jelly. ROYAL JELLY Royal jelly may help to relieve many of the symptoms associated with menopause. Thien FC, Leung R, Baldo BA, et al. Its known to have an antibacterial effect, which can keep wounds clean and free from infection (11). View abstract. In a 2014 study published in Complementary Therapies in Medicine, 110 female university students with PMS were given either 1,000 mg of royal jelly or a placebo. Int J Gynaecol Obstet 2008;101(2):146-149. WebResearch has found a number of potential health benefits to royal jelly: Antibacterial Properties Royal jelly has demonstrated antibacterial properties against a range of bacteria. Medicines (Basel) 2018;6(1):2. Our website services, content, and products are for informational purposes only. If you decide to freeze royal jelly, divide it into small portions first. Yamaga M, Tani H, Yamaki A, Tatefuji T, Hashimoto K. Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects. J.Dermatol. 1966;8(6):329-333. Other skin experts we queried went to bat for royal jelly, too. 2008;21(6):677-681. Int Immunopharmacol. The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial. Benefits have been observed in a wide range of dosages. View abstract. Oral intake of royal jelly improves anti-cancer effects and suppresses adverse events of molecular targeted therapy by regulating TNF-a and TGF-B in renal cell carcinoma: a preliminary study based on a randomized double-blind clinical trial. Royal jelly should never be refrozen once thawed. A contribution to chemical investigation of royal jelly and possibilities of applying it in therapy. Royal Jelly J Intercult Ethnopharmacol. Taking royal jelly with warfarin might increase the risk of bruising or bleeding. And there's interesting research suggesting royal jelly supplements may have anti-aging benefits. These include (2): Some of these extreme reactions could even be fatal. To date, many of the health claims associated with royal jelly remain unproven. Benefits Possible Side Effects How to Buy and Use Royal jelly is a milk-like substance secreted by bees that provides nutrition to developing larvae as well as the queen bee. Its proteins are vital for the growth of cells and may also play a role in reproduction. Morita, H., Ikeda, T., Kajita, K., Fujioka, K., Mori, I., Okada, H., Uno, Y., and Ishizuka, T. Effect of royal jelly ingestion for six months on healthy volunteers. 2008;13(4):330-333. View abstract. After two cycles, women in the royal jelly group had more than a 50% reduction in their PMS symptom score, while women in the placebo group had less than a 5% decrease. 1957;13(4):1023-1033. Abd-Alhafiz AT, Abd-Almonem J. But is it worth the expense? Current research supports possible benefits at 3006,000 mg per day (30). Librowski, T Czarnecki R. Comparative analysis of Apistmul Crataegi Forte and royal jelly in the experimental heart action disturbance. 2004;27(2):189-192. Sci Rep. 2017;7(1):11416. 2016 May;10(5):QC01-5. MRJP1 is the most abundant, and largest in size. One animal and one small human study showed improvements in chronic dry eyes for those treated orally with royal jelly. Royal Jelly Int Wound J. See additional information. Royal jelly can also be applied topically to your skin and is sometimes included in commercially available skin care products. 2014;28(4):242-6. It typically contains about 60% to 70% water, 12% to 15% proteins, 10% to 16% sugar, 3% to 6% fats, and 2% to 3% vitamins, salts, and amino acids. Seyyedi F, Rafiean-Kopaei M, Miraj S. Comparison of the Effects of Vaginal Royal Jelly and Vaginal Estrogen on Quality of Life, Sexual and Urinary Function in Postmenopausal Women. These days, it seems like there's always a new must-have skincare ingredient that promises to deliver the fountain of youth, clear your complexion for good, and change your tires. 2019;55(2):25. doi:10.3390/medicina55020025. Albert S, Bhattacharya D, Klaudiny J, et al. Effect of royal jelly intake on serum glucose, Apolipoprotein A-I (ApoA-I), Apolipoprotein B (ApoB) and ApoB/ApoA-I ratios in patients with type 2 diabetes: a randomized, double-blind clinical trial study. Asthma following royal jelly. One 12-week study found that rabbits supplemented with royal jelly significantly reduced their total and bad LDL cholesterol levels by 28% and 23%, respectively (8). View abstract. So while royal jelly and propolis are functionally similar from a skincare perspective, they're very different substancesand serve separate, super-fascinating purposes in the bee world. Additionally, several test-tube studies show reduced levels of pro-inflammatory chemicals released from immune cells treated with royal jelly (4, 5, 6). Effects of an herbal medication containing bee products on menopausal symptoms and cardiovascular risk markers: results of a pilot open-uncontrolled trial. Some types of honey have as many antioxidants as fruits and vegetables. Honey The family consists of nine proteins, of which MRJP1 (also called royalactin), MRJP2, MRJP3, MRJP4, and MRJP5 are present in the royal jelly secreted by worker bees. Treatment started on the first day of menstruation and continued through two menstrual cycles. 9-5-2003;73(16):2029-2045. Royal jelly liquid and paste are more shelf-stable but often include stabilizers and preservatives to prolong their expiration. View abstract. Propolis is a compound produced by bees thought to fight infections, heal wounds, and more. It is also used to increase endurance and well-being (not only to treat specific health conditions). Inoue S, Kawashima M, Hisamura R, et al. Royal jelly also contains several B vitamins and trace minerals. Journal of Otolaryngology -- Head & Neck Surgery. Royal jelly is a milk-like substance secreted by bees that provides nutrition to developing larvae as well as the queen bee. Oral administration of Royal Jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice. Sharif SN, Darsareh F. Effect of royal jelly on menopausal symptoms: a randomized placebo-controlled clinical trial.
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